Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

@article{Choo1989IsolationOA,
  title={Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.},
  author={Q-L. Choo and George C. Kuo and Amy J. Weiner and Lacy R. Overby and Daniel W. Bradley and Michael Houghton},
  journal={Science},
  year={1989},
  volume={244 4902},
  pages={
          359-62
        }
}
A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis (NANBH) agent and screened with serum from a patient diagnosed with NANBH. A complementary DNA clone was isolated that was shown to encode an antigen associated specifically with NANBH infections. This clone is not derived from host DNA but from an RNA molecule present in NANBH infections that consists of at least 10,000 nucleotides and that is positive-stranded with… 
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TLDR
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