Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

@article{BarreSinoussi1983IsolationOA,
  title={Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).},
  author={Françoise Barré-Sinoussi and Jean Claude Chermann and Françoise Rey and M. T. Nugeyre and Solange Chamaret and Jacqueline Gruest and Charles Dauguet and C Axler-Blin and F V{\'e}zinet-Brun and Christine Rouzioux and Willy Rozenbaum and Luc Montagnier},
  journal={Science},
  year={1983},
  volume={220 4599},
  pages={
          868-71
        }
}
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this… Expand
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Presence of viral antibodies to the human lymphoma-leukemia virus in patients with acquired immune deficiency syndrome
The acquired immune deficiency syndrome (AIDS) has been observed mainly in male homosexuals in the Western hemisphere, in intravenous drug addicts, and occasionally in haemophiliacs and inhabitants… Expand
Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.
TLDR
Another subgroup of HTLV, designated HTLV-III, has now been isolated from many patients with AIDS and pre-AIDS and is shown to be a true member of the HTLV family. Expand
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Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region, which place ARV in the lentivirus subfamily of human retroviruses. Expand
Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.
TLDR
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Further characterization of a human lymphotropic retrovirus previously isolated from a patient with lymphadenopathy syndrome is reported, which has a distinct morphology when examined by electron microscopy, close to that of equine infectious anaemia virus (EIAV). Expand
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