Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

  title={Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).},
  author={Françoise Barré-Sinoussi and Jean Claude Chermann and Françoise Rey and M. T. Nugeyre and Solange Chamaret and Jacqueline Gruest and Charles Dauguet and C Axler-Blin and F V{\'e}zinet-Brun and Christine Rouzioux and Willy Rozenbaum and Luc Montagnier},
  volume={220 4599},
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this… 

A human T-lymphotropic retrovirus (HTLV-III) as the cause of the acquired immunodeficiency syndrome.

Three human T-lymphotropic viruses have been isolated and characterized in the past 5 years and HTLV-III/lymphadenopathy-associated virus, which is implicated as the primary cause of the acquired immunodeficiency syndrome (AIDS), is identified.

A pathogenic retrovirus (HTLV-III) linked to AIDS.

There are new possibilities for identifying early cases of AIDS through antibody testing, and the discovery of an immunosuppressive retrovirus in AIDS could serve as a stimulus to re-examine endemic forms of cancer in Third World countries.

Molecular cloning of lymphadenopathy-associated virus

A cloned LAV complementary DNA was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes, and two families of clones were characterized which differ in a restriction site.

HTLV-V: a new human retrovirus isolated in a Tac-negative T cell lymphoma/leukemia.

The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.

Presence of viral antibodies to the human lymphoma-leukemia virus in patients with acquired immune deficiency syndrome

The acquired immune deficiency syndrome (AIDS) has been observed mainly in male homosexuals in the Western hemisphere, in intravenous drug addicts, and occasionally in haemophiliacs and inhabitants

Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.

Another subgroup of HTLV, designated HTLV-III, has now been isolated from many patients with AIDS and pre-AIDS and is shown to be a true member of the HTLV family.

Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features.

Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region, which place ARV in the lentivirus subfamily of human retroviruses.

Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.

Serum samples from 88 percent of patients with AIDS and from 79 percent of homosexual men with signs and symptoms that frequently precede AIDS, but from less than 1 percent of heterosexual subjects, have antibodies reactive against antigens of HTLV-III, and the major immune reactivity appears to be directed against p41, the presumed envelope antigen of the virus.

A molecular clone of HTLV-III with biological activity

It is demonstrated that this molecular clone is infectious in vitro and causes marked cytopathic effects on T-cell cultures, the first direct evidence that the HTLV-III genome, rather than a minor component of the virus complex, is cy topathic for T cells.



Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses

Observations agree with immunological comparisons between reverse transcriptase of HTLV CR and other retroviruses and nucleic acid sequence homology studies which indicate that the various HTLVCR isolates represent new retrovirus found in some human T-cell neoplasias.

A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia.

Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T- cell leukemias or lymphomas, but a related retrovirus has been found in a patient with a somewhat different disease.

Isolation and transmission of human retrovirus (human t-cell leukemia virus).

Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody

Results indicated that HTLV p19 expression is rare, possibly in a subset of mature T cell neoplasias, and the monoclonal antibody will be useful in determining the natural reservoir of HTLV.

Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein.

It is found that p60sarc, a protein present in normal cells at a low level, is associated with a protein kinase activity, and thus it too is similar by the above criteria to p60src of avian sarcoma virus.

Dissociation of β-Galactosidase by Thiols

Mercaptoethanol stabilizes the enzyme isolated from the K12 strain against thermal inactivation but Reithel and his coworkers observed that the enzyme from strain ML308 is readily inactivated in the presence of thiols.

Human retroviruses and adult T-cell leukemia-lymphoma.