Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

@article{BarreSinoussi1983IsolationOA,
  title={Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).},
  author={Françoise Barré-Sinoussi and Jean Claude Chermann and Françoise Rey and M. T. Nugeyre and Solange Chamaret and Jacqueline Gruest and Charles Dauguet and C Axler-Blin and F V{\'e}zinet-Brun and Christine Rouzioux and Willy Rozenbaum and Luc Montagnier},
  journal={Science},
  year={1983},
  volume={220 4599},
  pages={
          868-71
        }
}
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this… 
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A human T-lymphotropic retrovirus (HTLV-III) as the cause of the acquired immunodeficiency syndrome.

Three human T-lymphotropic viruses have been isolated and characterized in the past 5 years and HTLV-III/lymphadenopathy-associated virus, which is implicated as the primary cause of the acquired immunodeficiency syndrome (AIDS), is identified.

A pathogenic retrovirus (HTLV-III) linked to AIDS.

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Presence of viral antibodies to the human lymphoma-leukemia virus in patients with acquired immune deficiency syndrome

The acquired immune deficiency syndrome (AIDS) has been observed mainly in male homosexuals in the Western hemisphere, in intravenous drug addicts, and occasionally in haemophiliacs and inhabitants…

Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.

Another subgroup of HTLV, designated HTLV-III, has now been isolated from many patients with AIDS and pre-AIDS and is shown to be a true member of the HTLV family.

Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Clinical, biological, and molecular features.

Molecular studies of independent ARV isolates indicate a polymorphism of nucleotide sequences, particularly in the viral envelope region, which place ARV in the lentivirus subfamily of human retroviruses.

Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.

Serum samples from 88 percent of patients with AIDS and from 79 percent of homosexual men with signs and symptoms that frequently precede AIDS, but from less than 1 percent of heterosexual subjects, have antibodies reactive against antigens of HTLV-III, and the major immune reactivity appears to be directed against p41, the presumed envelope antigen of the virus.

A new type of retrovirus isolated from patients presenting with lymphadenopathy and acquired immune deficiency syndrome: Structural and antigenic relatedness with equine infectious anaemia virus

A molecular clone of HTLV-III with biological activity

It is demonstrated that this molecular clone is infectious in vitro and causes marked cytopathic effects on T-cell cultures, the first direct evidence that the HTLV-III genome, rather than a minor component of the virus complex, is cy topathic for T cells.
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