Isolation of a Neurotoxin (α-colubritoxin) from a Nonvenomous Colubrid: Evidence for Early Origin of Venom in Snakes

@article{Fry2003IsolationO,
  title={
Isolation of a Neurotoxin (α-colubritoxin) from a Nonvenomous Colubrid: Evidence for Early Origin of Venom in Snakes
},
  author={B. Fry and Natalie G. Lumsden and W. W{\"u}ster and J. C. Wickramaratna and W. Hodgson and R. Manjunatha Kini},
  journal={Journal of Molecular Evolution},
  year={2003},
  volume={57},
  pages={446-452}
}
The evolution of venom in advanced snakes has been a focus of long-standing interest. Here we provide the first complete amino acid sequence of a colubrid toxin, which we have called α-colubritoxin, isolated from the Asian ratsnake Coelognathusradiatus (formerly known as Elapheradiata), an archetypal nonvenomous snake as sold in pet stores. This potent postsynaptic neurotoxin displays readily reversible, competitive antagonism at the nicotinic receptor. The toxin is homologous with, and… Expand
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