Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats

@article{Reiner1993IsolationOA,
  title={Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats},
  author={O. Reiner and R. Carrozzo and Y. Shen and M. Wehnert and F. Faustinella and W. Dobyns and C. Caskey and D. Ledbetter},
  journal={Nature},
  year={1993},
  volume={364},
  pages={717-721}
}
  • O. Reiner, R. Carrozzo, +5 authors D. Ledbetter
  • Published 1993
  • Biology
  • Nature
    • LISSENCEPHALY (agyria-pachygyria) is a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration1,2. Identification of the gene(s) involved in this disorder would facilitate molecular dissection of normal events in brain development3. Type 1 lissencephaly occurs either as an isolated abnormality or in association with dysmorphic facial appearance in patients with Miller–Dieker syndrome4,5. About 15% of patients with isolated lissencephaly and more than 90… CONTINUE READING
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