Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development.

@article{Eggert1998IsolationOA,
  title={Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development.},
  author={Tanja Eggert and Bernd Hauck and Niko Hildebrandt and W. J. Gehring and Uwe Walldorf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={2343-8}
}
Vertebrate and invertebrate eye development require the activity of several evolutionarily conserved genes. Among these the Pax-6 genes play a major role in the genetic control of eye development. Mutations in Pax-6 genes affect eye development in humans, mice, and Drosophila, and misexpression of Pax-6 genes in Drosophila can induce ectopic eyes. Here we report the identification of a paired-like homeobox gene, DRx, which is also conserved from flies to vertebrates. Highly conserved domains in… CONTINUE READING

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