Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC.

@article{Namikawa1995IsolationOX,
  title={Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC.},
  author={Chisato Namikawa and Luisa Salter-Cid and Martin F. Flajnik and Yoichi Kato and Masaru Nonaka and Makoto Sasaki},
  journal={Journal of immunology},
  year={1995},
  volume={155 4},
  pages={1964-71}
}
The mammalian low molecular mass protein-7 (LMP-7) gene resides in the class II region of the MHC, and its product is most probably involved, as a component of a proteasome, in the processing of Ags to be presented by the MHC class I molecules. To elucidate the evolution of the LMP-7 gene at both the primary structure and genetic levels, we isolated LMP-7 cDNA clones from amphibian Xenopus laevis, which last shared a common ancestor with mammals 350 x 10(6) years ago. Two distinctive clones… CONTINUE READING

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