Isolation of SPINK6 in Human Skin

@article{MeyerHoffert2010IsolationOS,
  title={Isolation of SPINK6 in Human Skin},
  author={Ulf Meyer-Hoffert and Zhihong Wu and Tomasz Kantyka and Jan Fischer and Ties Latendorf and Britta Hansmann and Joachim Bartels and Yinghong He and Regine Gl{\"a}ser and Jens M. Schr{\"o}der},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={32174 - 32181}
}
Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are tightly controlled by specific inhibitors, including the lymphoepithelial Kazal-type inhibitor (LEKTI) encoded by SPINK5 and LEKTI-2 encoded by SPINK9. Herein, we identify SPINK6 as a selective inhibitor of KLKs in the skin. Unlike LEKTI but similar to LEKTI-2, SPINK6 possesses only one typical Kazal domain. Its mRNA was detected to be expressed at low levels in several tissues and was induced during… Expand
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TLDR
This study indicates that Spink6 is a potent inhibitor of KLKs and involved in skin barrier function. Expand
The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-typeExpand
Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic Cascade
TLDR
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Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.
TLDR
Chemical tools for studying KLK activity are unveiled and their potential for characterizing KLK biological functions in epidermal homeostasis is demonstrated, revealing that inhibition of KLK7 alone is sufficient to block shedding, whereas KLK5 is also a major contributor. Expand
The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin
TLDR
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TLDR
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