Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

@article{Xiao2020IsolationOS,
  title={Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins},
  author={Kangpeng Xiao and Junqiong Zhai and Yaoyu Feng and Niu Zhou and Xu Zhang and Jie-Jian Zou and Na Li and Yaqiong Guo and Xiaobing Li and Xuejuan Shen and Zhipeng Zhang and Fanfan Shu and Wanyi Huang and Yu Li and Ziding Zhang and Rui-ai Chen and Yajiang Wu and Shi-ming Peng and Mian Huang and Wei-Jun Xie and Qin-Hui Cai and Fanghui Hou and Wu Chen and Lihua Xiao and Yongyi Shen},
  journal={Nature},
  year={2020},
  volume={583},
  pages={286-289}
}
The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health 1 . The new coronavirus responsible for this outbreak—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG13 2 . Although bats may be the reservoir host for a variety of coronaviruses 3 , 4 , it remains unknown whether SARS-CoV-2 has additional host species. Here we show that a coronavirus, which we name… 
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References

SHOWING 1-10 OF 37 REFERENCES
Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins
TLDR
The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
TLDR
These results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs, and highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots.
A pneumonia outbreak associated with a new coronavirus of probable bat origin
TLDR
Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
From SARS to MERS, Thrusting Coronaviruses into the Spotlight
TLDR
The research still needed to fully elucidate the pathogenic mechanism of these viruses, to construct reproducible animal models, and ultimately develop countermeasures to conquer not only SARS-CoV and MERS-coV, but also these emerging coronaviral diseases are outlined.
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
TLDR
It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases.
Bats Are Natural Reservoirs of SARS-Like Coronaviruses
TLDR
It is reported that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak, and these viruses display greater genetic variation than SARS-CoV isolated from humans or from civets.
Origin and evolution of pathogenic coronaviruses
TLDR
The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
Civets Are Equally Susceptible to Experimental Infection by Two Different Severe Acute Respiratory Syndrome Coronavirus Isolates
TLDR
It is shown that civets were equally susceptible to SARS-CoV isolates GZ01 and BJ01, and the infection was confirmed by virus isolation, detection of viral genomic RNA, and serum-neutralizing antibodies.
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
TLDR
Camels serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus, according to surveillance in Saudi Arabia in 2014 and 2015.
Bats and Coronaviruses
TLDR
This review follows the CoV outbreaks that are speculated to have originated in bats and reviews studies that have allowed researchers to identify unique adaptation in bats that may allow them to harbor CoVs without severe disease.
...
1
2
3
4
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