Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-A

@inproceedings{Wollenberg2012IsolationOR,
  title={Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-A},
  author={Diana J. M. van den Wollenberg and Iris J. C. Dautzenberg and Sanne K. van den Hengel and Steve J. Cramer and Raoul J de Groot and Rob C Hoeben},
  booktitle={PloS one},
  year={2012}
}
Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D) is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A) on the target cells. Here, we describe the isolation and characterization of reovirus T3D mutants that can infect human tumor cells independent… CONTINUE READING