Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions.

  title={Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions.},
  author={Monica M Olcina and Amato J. Giaccia and Ester M Hammond},
  journal={Advances in experimental medicine and biology},
During S-phase both DNA replication and histone deposition must be co-ordinated at and around the replication fork. Replication stress can interfere with the fidelity of this process and can result in genomic instability. The study of proteins associated with DNA replication forks is important for a detailed understanding of DNA replication and chromatin assembly both under basal as well as replication stress conditions. iPOND (isolation of Proteins on Nascent DNA) allows the temporal study of… CONTINUE READING
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