Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells

@article{MayerProschel1997IsolationOL,
  title={Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells},
  author={Margot Mayer-Proschel and Anjali J Kalyani and Tahmina Mujtaba and Mahendra S. Rao},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={773-785}
}
We have identified a neuronal-restricted precursor (NRP) cell that expresses E-NCAM (high polysialic-acid NCAM) and is morphologically distinct from multipotent neuroepithelial (NEP) cells (Kalyani et al., 1997) and spinal glial progenitors (Rao and Mayer-Proschel, 1997). NRP cells self renew over multiple passages in the presence of fibroblast growth factor (FGF) and neurotrophin-3 (NT-3) and differentiate in the presence of retinoic acid and the absence of FGF into postmitotic neurons. NRP… CONTINUE READING

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