Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †

  title={Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †},
  author={Thomas H. Weller and Juliete Macauley and John M. Craig and P M Wirth},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={12 - 4}
Summary Viruses that produce similar cytopathic changes in vitro characterized by presence of intranuclear inclusions have been isolated from 3 infants during life. The first derived from a liver biopsy from a 3-months-old child (Davis) with microcephaly, persistent jaundice, and hepatosplenomegaly; cytomegalic cells were demonstrated in the liver specimen. From a second child, virus was isolated from a liver biopsy, and on three occasions between the 14th and 91st day of life from the urine… Expand
Cytomegalic inclusion disease uveitis; report of a case with isolation from aqueous humor of the virus in tissue culture.
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Cytomegalic inclusion disease or salivary gland virus disease is a pathologic entity that has been known since 1904 by the large intranuclear and intracytoplasmic inclusionbearing cells, 1 but it hasExpand
Chapter 23 – Cytomegalovirus Infections
The cellular changes observed in tissue sections from patients with a fatal infection led to the use of the term cytomegalic inclusion disease (CID) years before the causative agent was identified. Expand
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It seems that, like rubella and toxoplasmosis, cytomegalic inclusion disease may be an entity with a broad socialignificance, and the manifestations of the disease are apparent at birth and mothers of affected infants have been shown to be excreting the virus. Expand
Isolation of Cytomegalovirus in an Infant with an Angiosarcoma
This appears to be the first reported case in this country of the diagnosis of cytomegalovirus infection during life by virus isolation, and in which the possible source of the infection was traced by a family study. Expand
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A study was made of the occurrence of viruria, with particular reference to the cytomegaloviruses, in a group of 50 children with leukemia, lymphoma, or Hodgkin's disease, finding that one leukemic patient over a period of several weeks concurrently excreted two viruses in the urine, an adenovirus and a cytomeGalovirus. Expand
Adult Cytomegalic Inclusion Disease
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  • Medicine
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Most adult disease is thus the result of reactivation of the virus which has been latent for a variable number of years, and Hepatic disease in adults is well-known, and reactivation has been reported to have a higher incidence in alcoholics, but biliary tract involvement is apparently less common than in stillbirths and neonates. Expand
Generalized cytomegalic inclusion disease.
Three patients in whom the diagnosis of cytomegalic inclusion disease was established during life are reported, with the most severely involved infant dying at 1 year of age and two surviving infants aged 26 and 35 months of age. Expand
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Fetterman (1952) made the important observation that cytomegalic inclusion disease (CID) could be diagnosed during life by the demonstration of inclusion cells in urinary sediments, and was used with varying degrees of success for a number of years until the causative agent of the human disease was finally isolated. Expand
Human cytomegalovirus infection: Recent developments in diagnosis and epidemiology
A number of liquid- and solid-phase immunoassays have been developed, of which immunofluorescence and ELISA are most commonly used, besides complement fixation and passive haemaglutination, which allow an exact epidemiological identification of risk groups for CMV infection. Expand
Cell-Activation Responses to Cytomegalovirus Infection
Noting the unique and characteristic features of the cytopathology induced by these viruses, Weller et al. (1960) suggested that this group of viruses be renamed cytomegaloviruses (CMV). Expand