Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †

@article{Weller1957IsolationOI,
  title={Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †},
  author={Thomas H. Weller and Juliete Macauley and John M. Craig and P M Wirth},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1957},
  volume={94},
  pages={12 - 4}
}
Summary Viruses that produce similar cytopathic changes in vitro characterized by presence of intranuclear inclusions have been isolated from 3 infants during life. The first derived from a liver biopsy from a 3-months-old child (Davis) with microcephaly, persistent jaundice, and hepatosplenomegaly; cytomegalic cells were demonstrated in the liver specimen. From a second child, virus was isolated from a liver biopsy, and on three occasions between the 14th and 91st day of life from the urine… Expand
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  • A.M.A. archives of ophthalmology
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  • Medicine
  • Scottish medical journal
  • 1980
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  • Medicine
  • Archives of disease in childhood
  • 1971
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Fetterman (1952) made the important observation that cytomegalic inclusion disease (CID) could be diagnosed during life by the demonstration of inclusion cells in urinary sediments, and was used with varying degrees of success for a number of years until the causative agent of the human disease was finally isolated. Expand
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