Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †
@article{Weller1957IsolationOI,
title={Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.∗ †},
author={Thomas H. Weller and Juliete Macauley and John M. Craig and P M Wirth},
journal={Proceedings of the Society for Experimental Biology and Medicine},
year={1957},
volume={94},
pages={12 - 4}
}Summary Viruses that produce similar cytopathic changes in vitro characterized by presence of intranuclear inclusions have been isolated from 3 infants during life. The first derived from a liver biopsy from a 3-months-old child (Davis) with microcephaly, persistent jaundice, and hepatosplenomegaly; cytomegalic cells were demonstrated in the liver specimen. From a second child, virus was isolated from a liver biopsy, and on three occasions between the 14th and 91st day of life from the urine…
345 Citations
CYTOMEGALIC INCLUSION DISEASE
- Medicine, BiologyDevelopmental medicine and child neurology
- 1963
It seems that, like rubella and toxoplasmosis, cytomegalic inclusion disease may be an entity with a broad socialignificance, and the manifestations of the disease are apparent at birth and mothers of affected infants have been shown to be excreting the virus.
Isolation of Cytomegalovirus in an Infant with an Angiosarcoma
- MedicineArchives of disease in childhood
- 1963
This appears to be the first reported case in this country of the diagnosis of cytomegalovirus infection during life by virus isolation, and in which the possible source of the infection was traced by a family study.
Adult Cytomegalic Inclusion Disease
- MedicineScottish medical journal
- 1980
Most adult disease is thus the result of reactivation of the virus which has been latent for a variable number of years, and Hepatic disease in adults is well-known, and reactivation has been reported to have a higher incidence in alcoholics, but biliary tract involvement is apparently less common than in stillbirths and neonates.
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- Medicine, BiologyKlinische Wochenschrift
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A number of liquid- and solid-phase immunoassays have been developed, of which immunofluorescence and ELISA are most commonly used, besides complement fixation and passive haemaglutination, which allow an exact epidemiological identification of risk groups for CMV infection.
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- Medicine, BiologyPediatrics in review
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Fetterman (1952) made the important observation that cytomegalic inclusion disease (CID) could be diagnosed during life by the demonstration of inclusion cells in urinary sediments, and was used with varying degrees of success for a number of years until the causative agent of the human disease was finally isolated.
Cytomegalovirus infection.
- Medicine, BiologyArchives of disease in childhood
- 1971
Fetterman (1952) made the important observation that cytomegalic inclusion disease (CID) could be diagnosed during life by the demonstration of inclusion cells in urinary sediments, and was used with varying degrees of success for a number of years until the causative agent of the human disease was finally isolated.
Cell-Activation Responses to Cytomegalovirus Infection
- Medicine, Biology
- 1989
Noting the unique and characteristic features of the cytopathology induced by these viruses, Weller et al. (1960) suggested that this group of viruses be renamed cytomegaloviruses (CMV).