Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

  title={Isolation of Drosophila genes encoding G protein-coupled receptor kinases.},
  author={J Aaron Cassill and Mike Whitney and Claudio A P Joazeiro and Anke Becker and Charles S. Zuker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 24},
G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein… CONTINUE READING