Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica

@article{Abdallah2014IsolationOA,
  title={Isolation of Antiosteoporotic Compounds from Seeds of Sophora japonica},
  author={Hossam Mohamed Abdallah and Ahmed M. Al-Abd and Gihan F. Asaad and Ashraf B. Abdel-Naim and Ali M. El-Halawany},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4’-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α–L-rhamnopyranosyl(1→6)β-D-glucopyranosyl(1→2)β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell… 
Antimicrobial Activity of Sophora Japonica Extract Against Oral Bacteria
Background: The flower and flower buds of Sophora japonica L. have the same medicinal uses, with significant biological activity, in the treatment of bleeding hemorrhoids, hematuria, hematemesis,
Styphnolobium japonicum (L.) Schott Fruits Increase Stress Resistance and Exert Antioxidant Properties in Caenorhabditis elegans and Mouse Models
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The ability of the extract to enhance stress resistance was manifested through increasing survival rate and decreasing basal reactive oxygen species (ROS) levels and the extract significantly decreased the expression of the oxidative stress marker malondialdehyde (MDA).
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Fructus Sophorae (FS), the dry mature fruit of Sophora japonica Leguminosae, is a valuable traditional Chinese medicine resource with flavonoids as the major active ingredients. To identify the
The pharmacology of the genus Sophora (Fabaceae): An updated review.
TLDR
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TLDR
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Sophoricoside from Styphnolobium japonicum improves experimental atopic dermatitis in mice.
TLDR
Topical application of sophoricoside decreased the symptoms of AD-like allergic skin inflammation, including elevated hypertrophic scars with spongiotic epidermis, epidermal hyperplasia, hyperkeratosis, infiltration of immune, and mast cells, dermal thickness, amounts of immunoglobulins, and pro-inflammatory cytokines, and the mast cell population in the skin.
Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers
TLDR
Rutin enhances proliferation and ossification markers in bone cells and is found to enhance both, while decreasing acid phosphatase which is a marker of osteoporosis.
Phenolics Isolated from Aframomum meleguta Enhance Proliferation and Ossification Markers in Bone Cells
TLDR
P paradol, which is a major constituents of A. melegueta seeds, exhibited potent proliferative and ossification characteristics in bone cells and enhanced alkalineosphatase activity and vitamin D content and decreased the osteoporotic marker acid phosphatase.
Flavonoids From the Flowers of Sophora davidii and Their Anti-Tobacco Mosaic Virus Activities
A new pterocarpan, named davidicarpan A (1), together with 9 known flavonoids, including 3 pterocarpans (2-4) and 6 isoflavones (5-10), were isolated from the flowers of Sophora davidii (France.)
Ethanolic extract of Sophora japonica flower buds alleviates cognitive deficits induced by scopolamine in mice
Sophora japonica has been shown many beneficial pharmacological activities, including the neuroprotective effects. Flavonoids, isoflavonoids, triterpenes, alkaloids are bioactive compounds identified
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Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica.
TLDR
The position of O-glycosylation and number of hydroxy groups in the isoflavonoids seem to play an important role in the inhibitory effect in the IL-5 bioassay.
Isolation and identification of antioxidants from Sophora japonica
TLDR
Compounds 1 - 3 showed antioxidative activity in DPPH and cytochrome-c assay using HL-60 cell system and one- and two-dimensional NMR spectroscopy, including DEPT, NOESY, DQF-COSY, TOCSY, HMQC, and HMBC experiments.
Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis.
TLDR
The results indicated that treatment with a 4.5 or 9 mg/kg dosage of genistein could also prevent osteoporosis significantly at the 4th week after treatment, which is in comparison with the anti-osteoporotic effects of soybean geniste in a small scale.
Triterpene glycosides ofSophora japonica seeds
We have isolated from the seeds of Sophora japonica the known soyasaponogenol B-3-[O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranuronoside] (adzukisaponin II), soyasapogenol B
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The results suggest that DFE may represent a useful remedy for the treatment of bone reabsorption diseases such as osteoporosis.
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TLDR
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TLDR
Three new isoflavonoid glycosides together with six known ones were isolated from the ingredients of Lupinus luteus L. and L. polyphyllus×arboreus hybrid, and it was shown that the is oflavonoids distributions in the two species were differed.
Dichloromethane extracts of Sophora japonica L. stimulate osteoblast differentiation in mesenchymal stem cells.
TLDR
Genistein was identified as the key phytoestrogen responsible for the effects of S japonica L. on osteoblast differentiation and the genistein in the DCM extracts mediated the pro-osteogenic effects.
Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt
TLDR
The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity and sophoricoside showed weak estrogenic activity on ERβ only.
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TLDR
Sophoricoside can be efficient in preventing ovariectomy-induced bone loss in rats and should be given orally for one month.
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