Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

@article{Davis1996IsolationOA,
  title={Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning},
  author={Samuel Davis and Thomas H. Aldrich and Pamela F. Jones and Ann L. Acheson and Debra L Compton and Vivek Jain and Terence E. Ryan and Joanne Bruno and Czeslaw H Radziejewski and Peter C. Maisonpierre and George D. Yancopoulos},
  journal={Cell},
  year={1996},
  volume={87},
  pages={1161-1169}
}

Figures from this paper

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TLDR
This study analyzed how cell adhesion influences Ang1-dependent Tie2 signalling in terms of receptor phosphorylation and activation of Akt and Erk to confirm and provide a better characterization of the cross-talk between Tie2 and Integrins, shedding light on the important role of α2 and α5 integrins.
Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.
TLDR
The Tie-2 receptor tyrosine kinase transduces embryonic endothelial differentiation, with Angiopoietin-1 (Ang-1) acting as a stimulatory ligand and Ang-2 postulated to be a naturally occurring inhibitor, is shown to have roles in maturation of both glomeruli and vasa rectae.
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In vivo analyses of embryos deficient in Tie-2 showed that it is important in angiogen-esis, particularly for vascular network formation in endothelial cells, which contrasts with previous reports on Tie-1 function in vasculogenesis and/or endothelial cell survival.
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
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It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
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Tie-1 and tie-2 may form another class within the receptor tyrosine kinase gene family, and further characterization of these genes and identification of their putative ligands should define the nature of the signal-transduction cascades underlying early vascular system development, as well as their differential roles in mesodermal cells of the amniotic and myeloid lineages.
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It is concluded that TIE is required during embryonic development for the integrity and survival of vascular endothelial cells, particularly in the regions undergoing angiogenic growth of capillaries.
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TLDR
Characterization of two novel genes of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK, which shared a unique structural property of coexistent immunoglobulin-like domain, epidermal growth factor-like repeats, and fibronectin type III repeats in their extracellular domains.
Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells.
TLDR
In vitro colony assays and cell transfer experiments of fetal liver cells into lymphocyte-deficient recombination-activating-gene-2-/- mice reveal that Tie1-/- hematopoietic progenitor cells can generate myeloid lineages as well as T and B lymphocytes.
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