Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance.

@article{Heenan1997IsolationFA,
  title={Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance.},
  author={Mary Heenan and Lorraine O'Driscoll and I M Cleary and Lynn Connolly and Martin M. Clynes},
  journal={International journal of cancer},
  year={1997},
  volume={71 5},
  pages={907-15}
}
The heterogeneous nature of an adriamycin-selected human MDR squamous lung cell line, DLKP-A, was investigated by isolating and characterising 9 of its clonal subpopulations. The DLKP-A cell line exhibits resistance to the classical MDR drugs, overexpresses P-glycoprotein and displays reduced topoisomerase II amounts. The clonal cell lines exhibit a wide range of resistance extents, with the most resistant clone displaying 9 times the extent of adriamycin resistance observed in the least… CONTINUE READING
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