Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors.

@article{Adams1999IsolationAT,
  title={Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors.},
  author={Gregor B. Adams and Meghan McMullen and S J Turner and Ivona T. Olszak and David T Scadden and Myra O. McClure and Mark C. Poznansky},
  journal={Journal of acquired immune deficiency syndromes},
  year={1999},
  volume={21 1},
  pages={1-8}
}
A proposed hemopoietic stem cell gene therapy for treatment for HIV infection would involve transduction of CD34+ hemopoietic stem cells with vectors encoding anti-HIV constructs. Peripheral blood has proved to be a useful source of these hemopoietic stem cells and this study exploits this finding. Small quantities of peripheral blood were obtained from HIV… CONTINUE READING