Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest.

  title={Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest.},
  author={Ende Pan and S. Cao and P. Brodie and M. Callmander and Richard Randrianaivo and S. Rakotonandrasana and Etienne Rakotobe and V. Rasamison and Karen Tendyke and Yongchun Shen and E. M. Suh and D. Kingston},
  journal={Journal of natural products},
  volume={74 5},
Investigation of the Madagascan endemic plant Ambavia gerrardii for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the three new alkaloids 8-hydroxyeupolauridine (1), 9-methoxyeupolauridine 1-oxide (2), and 11-methoxysampangine (3) and the three known alkaloids 4-6. The structures of 1 and 2 were confirmed by synthesis. Compounds 3, 4, and 6 showed moderate to good antiproliferative activities, with IC50 values of 10.3, 3.5, and 0.60 μM… Expand
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