Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).

@article{Revesz1999IsolationAS,
  title={Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).},
  author={Laszlo Revesz and Peter C Hiestand and Luigi La Vecchia and Reto Naef and Hans-Peter N{\"a}geli and Lukas Oberer and Hermann Roth},
  journal={Bioorganic & medicinal chemistry letters},
  year={1999},
  volume={9 11},
  pages={1521-6}
}
The novel triterpene 1 with a dammarane skeleton and a hitherto unknown 17alpha-substitution pattern has been isolated from the Palmyrah palm in low yield and prepared by synthesis in larger quantities. 1 was shown to be an extremely potent immunosuppressant in vitro (MLR; IC50 = 10 ng/ml) and in vivo (DTH; ED50 = 0.01 mg/kg p.o.). A glucocorticoid like activity is excluded. 
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