Isolation and synthesis of a new aromatic compound, brefelamide, from dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.

Abstract

[structure: see text] We have explored the diversity of secondary metabolites produced by cellular slime molds to examine the possible use of such cellular slime molds as a resource for novel drug development. A new aromatic amide, brefelamide (1), was isolated from methanol extracts of the fruiting bodies of Dictyostelium brefeldianum and D. giganteum. The structure of 1 was determined by spectral means including EIMS and (1)H and (13)C NMR. The total synthesis of 1 was carried out to confirm the structure and obtain sufficient samples for performing biological evaluation. Interestingly, compound 1 inhibited the cellular proliferation of 1321N1 human astrocytoma cells.

Cite this paper

@article{Kikuchi2005IsolationAS, title={Isolation and synthesis of a new aromatic compound, brefelamide, from dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.}, author={Haruhisa Kikuchi and Yoshinori Saito and Jun'ichi Sekiya and Yumiko Okano and Masaki Saito and Norimichi Nakahata and Yuzuru Kubohara and Yoshiteru Oshima}, journal={The Journal of organic chemistry}, year={2005}, volume={70 22}, pages={8854-8} }