Isolation and study of an acquired inhibitor of human coagulation factor V.

@article{Nesheim1986IsolationAS,
  title={Isolation and study of an acquired inhibitor of human coagulation factor V.},
  author={Michael E. Nesheim and William L. Nichols and T L Cole and John Graeme Houston and Robert Schenk and Kenneth G. Mann and E. J. Walter Bowie},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 2},
  pages={405-15}
}
A coagulation Factor V inhibitor developed in a man 75 yr of age in association with an anaplastic malignancy and drug treatment (including the aminoglycoside antibiotic, gentamicin). The patient did not bleed abnormally, despite both surgical challenge and plasma Factor V activity of less than 1%. The inhibited plasma had grossly prolonged prothrombin and… CONTINUE READING