Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.

@article{Takada2001IsolationAS,
  title={Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.},
  author={Norio Takada and Motonobu Watanabe and Akane Yamada and Kiyotake Suenaga and Kaoru Yamada and Kazunori Ueda and Daisuke Uemura},
  journal={Journal of natural products},
  year={2001},
  volume={64 3},
  pages={356-9}
}
Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines. 

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