Isolation and structure of novel defensive peptides from frog skin.

@article{Mor1994IsolationAS,
  title={Isolation and structure of novel defensive peptides from frog skin.},
  author={A. Mor and P. Nicolas},
  journal={European journal of biochemistry},
  year={1994},
  volume={219 1-2},
  pages={
          145-54
        }
}
  • A. Mor, P. Nicolas
  • Published 1994
  • Biology, Medicine
  • European journal of biochemistry
In addition to the highly specific cell-mediated immune system, vertebrates possess an efficient host-defense mechanism against invading microorganisms which involves the synthesis of highly potent antimicrobial peptides with a large spectrum of activity. A 34-residue cationic and amphiphatic peptide, designated dermaseptin I, was recently isolated from the skin of the arboreal frog Phyllomedusa sauvagii and was shown to exhibit microbicidal activity against various pathogenic microorganisms… Expand
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The existence of antimicrobial peptides in the stomach of the vertebrate Xenopus laevis is reported and immunohistochemical studies demonstrate that magainin is stored in a novel granular multinucleated cell in the gastric mucosa of Xenopus. Expand
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A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis and appears to represent a previously unrecognized class of vertebrate antimicrobial activities. Expand
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  • J. Daly, J. Caceres, +5 authors C. W. Myers
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
A frog used for "hunting magic" by several groups of Panoan-speaking Indians in the borderline between Brazil and Peru is identified as Phyllomedusa bicolor, which has a peptide that is named adenoregulin, with the sequence GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV as determined from mass spectrometry and Edman degradation. Expand
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