Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.

  title={Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.},
  author={G. Pettit and Qingwen Zhang and V. Pinilla and D. Herald and D. Doubek and J. Duke},
  journal={Journal of natural products},
  volume={67 6},
  • G. Pettit, Qingwen Zhang, +3 authors J. Duke
  • Published 2004
  • Biology, Medicine
  • Journal of natural products
  • A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination. 
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