Isolation and structural elucidation of new peptaibols, bergofungins B, C and D, from Emericellopsis donezkii HKI 0059.

  title={Isolation and structural elucidation of new peptaibols, bergofungins B, C and D, from Emericellopsis donezkii HKI 0059.},
  author={Albrecht Berg and Brigitte Schlegel and Wolfgang Ihn and Ulrich Demuth and Udo Gr{\"a}fe},
  journal={The Journal of antibiotics},
  volume={52 7},
14-Residue peptaibol velutibol A from Trichoderma velutinum: its structural and cytotoxic evaluation
Velutibol A (1), a new 14-residue peptaibol was isolated from the Himalayan cold habitat fungus Trichoderma velutinum. The structural characterization was carried out by 1D and 2D NMR studies, and
A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina
A novel antibiotic peptide is isolated from the culture medium of Emericellopsis alkalina that exhibited a strong antifungal effect against the yeast Candida albicans, the mold fungus Aspergillus niger, and human pathogen clinical isolates and exhibited antimicrobial activity against some Gram-positive and Gram-negative bacteria.
Antimicrobial potential of alkalophilic micromycetes Emericellopsis alkalina
Evaluation of the spectrum and the yield of antibiotic compounds has allowed us to choose a promising producer of peptide antimycotics, Emericellopsis аlkalinа А118, which exhibits antifungal activity against conditionally pathogenic yeast and mold fungi.
Correction to "Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T)".
T corrections have been made in the references, and the corrected citations are as follows: (1) Degenkolb, T.; Brückner, H. Chem. Biodiversity 2008, 5, 1817−1843. (2) Stoppacher, N.; Neumann, N. K.
Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T).
Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid
A new bicyclic sesquiterpene from the marine sponge associated fungus Emericellopsis minima
Compounds 1 and cis -(3 R , 4 R )-4-hydroxymellein were found to show neither antimicrobial nor the in vitro growth inhibitory activities on three human tumor cell lines.
Isovaline in naturally occurring peptides: A nondestructive methodology for configurational assignment.
The recently developed (1)H-NMR method, which enables the nondestructive assignment of the configuration of each Iva residue in a peptide of known helical screw sense, was applied and proved to be generally applicable and provided evidence that, in the peptaibiotic bergofungin A, the Iva(12) configuration is (R) and not (S) as reported previously.
Stereoselective synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD)
The stereocontrolled synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid was accomplished using a glutamate derivative as starting material using an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction.
Asperelines A-F, peptaibols from the marine-derived fungus Trichoderma asperellum.
Fermentation of the marine-derived fungus Trichoderma asperellum resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N- terminus and a C-terminus containing an uncommon prolinol residue.
Peptaibiomics: Towards a Myriad of Bioactive Peptides Containing Cα‐Dialkylamino Acids?
Owing to the ubiquity and biodiversity of the fungal producers in the biosphere, the discovery of a myriad of peptaibiotics within the next decade is predicted.


Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.
Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.
Abstract The membrane activity of new 15-membered peptaibol-type antibiotics, ampullosporin (I) from Sepedonium ampullosporum and bergofungin (II) from Emericellopsis donezkii , was tested by use of
Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). II. Inhibitory activities and specificity.
The new proline-containing lipohexapeptide lipo hexin (I) isolated from three fungal strains is a competitive inhibitor of prolyl endopeptidase (PEP) from human placenta with IC50 of 3.5 microM.
Fungal metabolites. XV. Primary structures of antibiotic peptides, hypelcins B-I, B-II, B-III, B-IV and B-V, from Hypocrea peltata. Application of electrospray mass spectrometry and electrospray mass spectrometry/mass spectrometry.
Hypelcin B is a mixture of antibiotic peptides produced by Hypocrea peltata purified by reversed-phase high-performance liquid chromatography and the amino acid sequences of these peptides were determined by electrospray mass spectrometry and electrosPRay mass Spectrometry/mass spectromaetry.
The biophysics of peptide models of ion channels.
  • M. Sansom
  • Chemistry, Medicine
    Progress in biophysics and molecular biology
  • 1991
Application of Marfey's reagent in racemization studies of amino acids and peptides.
Reversed-phase high-performance liquid chromatography and pre-column derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey's reagent) were used for monitoring racemization in
Evaluation of fast atom bombardment mass spectrometry for sequence determination of peptides
16 Synthetic tri- to hexapeptides and a number of unknown peptides isolated from degradations of a locust cuticle protein are analysed by fast atom bombardment mass spectrometry. The analysis