Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.

@article{PrezVictoria2012IsolationAS,
  title={Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.},
  author={Ignacio P{\'e}rez-Victoria and Jesus Pena Martin and V{\'i}ctor Gonz{\'a}lez-Men{\'e}ndez and Nuria de Pedro and Noureddine el Aouad and Francisco Javier Ortiz-L{\'o}pez and Jos{\'e} R. Tormo and Gonzalo Platas and Francisca Vicente and Gerald F Bills and Olga Genilloud and Michael A. Goetz and Fernando Martinez Reyes},
  journal={Journal of natural products},
  year={2012},
  volume={75 6},
  pages={1210-4}
}
Three new cyclic tetrapeptides (1-3) have been isolated from the crude fermentation extract of Onychocola sclerotica. The planar structures of 1-3 were elucidated by detailed spectroscopic analyses using one- and two-dimensional NMR experiments and high-resolution mass spectrometry. The absolute configuration of the amino acid residues in each cyclotetrapeptide was established by Marfey's method. Compounds 1-3 displayed activity as cardiac calcium channel blockers (Cav1.2) but did not inhibit… CONTINUE READING