Isolation and restriction map of the V-J interval of the human T cell receptor gamma chain locus.

The human T cell receptor gamma chain locus encodes the immunoglobulin-like gamma chain polypeptide and spans a distance of approximately 150 kb. Previous studies have not precisely characterized the interval separating variable regions from joining--constant regions which is excised during gamma gene rearrangement. We report a series of overlapping cosmids… CONTINUE READING