[Isolation and properties of the protein C activator from Agkistrodon halys halys venom].

Abstract

Protein C activator from Agkistrodon halys halys venom has been purified by ion-exchange and gel-filtration chromatography. The purified enzyme consists of a single peptide chain with molecular weight of 34 kD. Its pH-optimum was the range of 7,5-8,0. The enzyme was inhibited by DFP, benzamidine, PMSF, EGTA. Protein C activator was as effective as Protac (Pentapharm AG, Switzerland) for determination of protein C level in blood plasma using APTT test and protein C chromogenic substrate.

Cite this paper

@article{Gornitskaia2003IsolationAP, title={[Isolation and properties of the protein C activator from Agkistrodon halys halys venom].}, author={O V Gornitskaia and Tatiana N. Platonova}, journal={Biomedit︠s︡inskai︠a︡ khimii︠a︡}, year={2003}, volume={49 5}, pages={470-8} }