Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus.

@article{Yeh2002IsolationAP,
  title={Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus.},
  author={S Z Yeh and Y. Chen and Annie C. Y. Chang and Rabindranath Ray and Bin-Ru She and Wen-Sen Lee and H N Chiang and Stanley N. Cohen and Sue Lin-Chao},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 8},
  pages={6311-7}
}
Growth arrest-specific (Gas) genes are expressed during serum starvation or contact inhibition of cells grown in culture. Here we report the isolation and characterization of Gas8, a novel gene identified on the basis of its growth arrest-specific expression in murine fibroblasts. We show that production of Gas8 mRNA and protein occurs in adult mice predominantly in the testes, where expression is regulated during postmeiotic development of male gametocytes. Whereas a low level of Gas8 mRNA was… CONTINUE READING
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