Isolation and preliminary characterisation of twenty-five temperature-sensitive mutants of mouse cytomegalovirus.

@article{Akel1993IsolationAP,
  title={Isolation and preliminary characterisation of twenty-five temperature-sensitive mutants of mouse cytomegalovirus.},
  author={H M Akel and Clive Sweet},
  journal={FEMS microbiology letters},
  year={1993},
  volume={113 3},
  pages={
          253-60
        }
}
To study the pathogenicity of mouse cytomegalovirus (MCMV) and to identify virulence determinants, we have isolated and phenotypically characterised 25 temperature-sensitive (ts) mutants. Six of these (tsm9, tsm13, tsm20, tsm22, tsm28 and tsm30) failed to replicate in mice and were avirulent. Five mutants (tsm14, tsm18, tsm19, tsm25 and tsm27) were of similar virulence to the parental wild-type (wt) virus, five (tsm7, tsm15, tsm24, tsm26 and tsm31) were 12-100 fold less virulent, five (tsm8… CONTINUE READING

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