Isolation and pharmacological characterization of two functional splice variants of corticotropin-releasing factor type 2 receptor from Tupaia belangeri.

@article{Palchaudhuri1999IsolationAP,
  title={Isolation and pharmacological characterization of two functional splice variants of corticotropin-releasing factor type 2 receptor from Tupaia belangeri.},
  author={Monika Palchaudhuri and Richard L. Hauger and Sandra Wille and Elaine Fuchs and Frank M. Dautzenberg},
  journal={Journal of neuroendocrinology},
  year={1999},
  volume={11 6},
  pages={419-28}
}
From brain, heart and muscle tissue of the tree shrew (Tupaia belangeri), a higher order mammal, cDNA clones were isolated that encoded two functional splice variants of the corticotropin-releasing factor (CRF) type 2 receptor (CRF-R2). The first, full-length splice variant, amplified from brain and heart tissue, encoded a CRF receptor protein that is 410 amino acids in length and approximately 96% homologous to human CRF-R2alpha. The second, full-length splice variant, derived from skeletal… CONTINUE READING

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