Isolation and partial characterization of nigrin b, a non-toxic novel type 2 ribosome-inactivating protein from the bark of Sambucus nigra L.

@article{Girbs1993IsolationAP,
  title={Isolation and partial characterization of nigrin b, a non-toxic novel type 2 ribosome-inactivating protein from the bark of Sambucus nigra L.},
  author={Tom{\'a}s Girb{\'e}s and Luc{\'i}a Citores and Jos{\'e} M Ferreras and Mar{\'i}a Angeles Rojo and Rosario Iglesias and Raquel Mu{\~n}oz and Francisco Javier Arias and Margarita Calonge and Jose Ramon Garc{\'i}a and Eduardo M{\'e}ndez},
  journal={Plant molecular biology},
  year={1993},
  volume={22 6},
  pages={1181-6}
}
The bark of Sambucus nigra L. contains a non-toxic novel type 2 ribosome-inactivating protein that we named nigrin b. In vitro, nigrin b strongly inhibited mammalian protein synthesis but did not affect plant nor bacterial protein synthesis. The protein (M(r) 58,000) contains two subunits, A (M(r) 26,000) and B (M(r) 32,000); linked by disulphide bridge(s). Nigrin b was found to be an rRNA N-glycosidase of the rRNA of intact mammalian ribosomes and shares a very good N-terminal amino-acid… CONTINUE READING

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