Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.

@article{Caro1997IsolationAP,
  title={Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.},
  author={Heinrich Caro and Sirilaksana Kunjara and Thomas William Rademacher and Y. Calder{\'o}n Le{\'o}n and David R. Jones and Matias A Avila and Isabel Varela-Nieto},
  journal={Biochemical and molecular medicine},
  year={1997},
  volume={61 2},
  pages={
          214-28
        }
}
Extracts of human liver were found to contain activities which copurified and coeluted with the two major subtypes of mediators (type A and type P) isolated from insulin-stimulated rat liver. The putative type A mediator from human liver inhibited cAMP-dependent protein kinase from bovine heart, decreased phosphoenolypyruvate carboxykinase mRNA levels in rat hepatoma cells, and stimulated lipogenesis in rat adipocytes. The putative type P mediator stimulated bovine heart pyruvate dehydrogenase… CONTINUE READING
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