Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32.

@article{Nishiwaki2000IsolationAM,
  title={Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32.},
  author={Tadashi Nishiwaki and Yataro Daigo and Teru Kawasoe and Yusuke Nakamura},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={27 2},
  pages={169-76}
}
The long arm of chromosome 9 is thought to contain one or more putative tumor suppressor genes that are mutated in squamous cell carcinomas. This region shows frequent loss of heterozygosity (LOH) in carcinomas arising in several developmentally related tissues, including the esophagus, head and neck, lung, and urinary bladder. We previously delineated the commonly deleted region in a panel of esophageal squamous cell carcinomas to a approximately 200 kb genomic segment at 9q32. Here we report… CONTINUE READING