Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells.

@article{Wang1995IsolationAM,
  title={Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells.},
  author={Shu-Mei Wang and Ming F. Tam and Ye Shih Ho and Soo Hwan Pai and Michael Kao},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1260 3},
  pages={285-93}
}
A vincristine-resistant lymphoma cell line (HOB1/VCR1.0) that is resistant to 1.0 microM of vincristine has been established from a human immunoblastic B lymphoma cell line, HOB1. HOB1/VCR1.0 cells demonstrated the typical multidrug resistant phenotypes. Using two-dimensional gel electrophoresis, we discovered one protein with a molecular mass of 22 kDa and pI 5.7 that was overexpressed in HOB1/VCR1.0 cells. This protein was purified to the degree of apparent homogeneity by preparative… CONTINUE READING

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