Isolation and molecular cloning of a fast-growing strain of human hepatitis A virus from its double-stranded replicative form.

@article{Venuti1985IsolationAM,
  title={Isolation and molecular cloning of a fast-growing strain of human hepatitis A virus from its double-stranded replicative form.},
  author={Aldo Venuti and C Di Russo and Nicoletta Del Grosso and Anna Maria Patti and Franco Ruggeri and P R De Stasio and M G Martiniello and P Pagnotti and Anna Marta Degener and Mario Midulla},
  journal={Journal of virology},
  year={1985},
  volume={56 2},
  pages={579-88}
}
A fast-growing strain of human hepatitis A virus was selected and characterized. The virus has the unusual property of developing a strong cytopathic effect in tissue culture in 7 to 10 days. Sequences of the viral genome were cloned into recombinant plasmids with the double-stranded replicative form as a template for the reverse transcription of cDNA. Restriction analysis and direct sequencing indicate that this strain is different from that described by Ticehurst et al. (Proc. Natl. Acad. Sci… CONTINUE READING

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