Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.

@article{Muriithi2002IsolationAI,
  title={Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.},
  author={Margaret W. Muriithi and Wolf-Rainer Abraham and Jonathan Addae-Kyereme and Ian J. Scowen and Simon L. Croft and Peter M. Gitu and Howard D Kendrick and Eliud N. M. Njagi and Colin W Wright},
  journal={Journal of natural products},
  year={2002},
  volume={65 7},
  pages={
          956-9
        }
}
Seven alkaloids have been isolated from Teclea trichocarpa including four, normelicopicine (1), arborinine (2), skimmianine (6), and dictamnine (7), that are reported for the first time in addition to the previously reported alkaloids melicopicine (3), tecleanthine (4), and 6-methoxytecleanthine (5). The structure of 1 was confirmed by single-crystal X-ray crystallography. Two alkaloids, 1 and 2, displayed limited in vitro activities against Plasmodium falciparum strains HB3 and K1, but there… Expand
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