Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.

  title={Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus.},
  author={Muhammad Ahmed Mesaik and Shahnaz Murad and Khalid Mohammed Khan and Rasool Bakhsh Tareen and Aqeel Ahmed and Mohammad Iqbal Choudhary},
  journal={Phytotherapy research : PTR},
  volume={23 11},
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10(-8) m) stimulated… CONTINUE READING

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