Isolation and identification of metabolites of osthole in rats.

@article{Lv2012IsolationAI,
  title={Isolation and identification of metabolites of osthole in rats.},
  author={Xinyou Lv and C Wang and Jianzhang Hou and B Zhang and Shuhua Deng and Yingying Tian and S-S Huang and H Zhang and X-H Shu and Y-H Zhen and K-X Liu and J-H Yao and X-c Ma},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2012},
  volume={42 11},
  pages={1120-7}
}
Osthole (Ost), one of the major components of Cnidium monnieri (L.) Cusson, is had the structure of an isopentenoxy-coumarin with a range of pharmacological activities. In the present study, the metabolism of Ost in male Sprague-Dawley rats was investigated by identifying Ost metabolites excreted in rat urine. Following an oral dose of 40 mg/kg Ost, 10 phase I and 3 phase II metabolites were isolated from the urine of rats, and their structures identified on the basis of a range of… CONTINUE READING

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