Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.

@article{Shimomura1999IsolationAI,
  title={Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.},
  author={Yukio Shimomura and Masatomo Mori and Tsukasa Sugo and Yoshihiro Ishibashi and Michiko Abe and Tomofumi Kurokawa and Haruo Onda and Osamu Nishimura and Yasuhiro Sumino and Masahiko Fujino},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 3},
  pages={
          622-6
        }
}
Melanin-concentrating hormone (MCH), which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor. We established a CHO cell line expressing the rat SLC-1 receptor to search for its endogenous ligand. The extract of rat whole brain showed inhibition of intracellular forskolin-induced cAMP accumulation in rat SLC-1-expressing CHO cells and was purified. Using HPLC purification, we isolated and identified MCH as the endogenous ligand of the SLC-1… CONTINUE READING
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