Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to.

@article{Hisha1997IsolationAI,
  title={Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to.},
  author={Hiroko Hisha and Hiroyuki Yamada and Masumi H. Sakurai and Hiroaki Kiyohara and Yanjun Li and Chia Li Yu and Norishige Takemoto and Harukiyo Kawamura and Ken Yamaura and Syuichi Shinohara and Yasuhiro Komatsu and Masaki Aburada and Susumu Ikehara},
  journal={Blood},
  year={1997},
  volume={90 3},
  pages={
          1022-30
        }
}
We have previously found that TJ-48 has the capacity to accelerate recovery from hematopoietic injury induced by radiation and the anti-cancer drug mitomycin C (MMC). The effects are found to be due to its stimulation of spleen colony-forming unit (CFU-S) counts on day 14. In the present study, we attempt to isolate and purify the active components in TJ-48 extracts using a new in vitro hematopoietic stem cell (HSC) assay method. n-Hexane extract from TJ-48 shows a significant stimulatory… CONTINUE READING

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