Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.

@article{Jonassen2000IsolationAF,
  title={Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.},
  author={Tanya Jonassen and Catherine F. Clarke},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 17},
  pages={12381-7}
}
The COQ3 gene in Saccharomyces cerevisiae encodes an O-methyltransferase required for two steps in the biosynthetic pathway of ubiquinone (coenzyme Q, or Q). This enzyme methylates an early Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-Q to Q. This enzyme is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol. A full-length cDNA encoding the human homologue of COQ3… CONTINUE READING
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