Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis.

@article{McGonigal2009IsolationAF,
  title={Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis.},
  author={Katrina McGonigal and Jamshid Tanha and Elitza Palazov and Shenghua Li and Deyzi Gueorguieva-Owens and Siyaram Pandey},
  journal={Applied biochemistry and biotechnology},
  year={2009},
  volume={157 2},
  pages={226-36}
}
Apoptosis, or programmed cell death, is an essential process affecting homeostasis of cell growth, development, and the elimination of damaged or dangerous cells. Inappropriate cell death caused by oxidative stress has been implicated in the development of neurodegenerative diseases such as Alzheimer's, Parkinson's, and stroke. On the other hand, a defect in the cell death process leads to the development of cancer. For example, the main player of apoptosis, p53, is defective in many of the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 24 references

biochemical aspects and clinical implications

F. L. Kiechle, Zhang, X. . Apoptosis
Clinica Chimica Acta, 326, 27–45. 236 Appl Biochem Biotechnol • 2009
View 1 Excerpt

Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2006
View 5 Excerpts

Intrabody applications in neurological disorders: progress and future prospects.

Molecular therapy : the journal of the American Society of Gene Therapy • 2005
View 2 Excerpts

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