Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

@article{Ali2015IsolationAE,
  title={Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma},
  author={H. Ali and S. Dixit and D. Ali and S. Alqahtani and S. H. Alkahtani and S. Alarifi},
  journal={Drug Design, Development and Therapy},
  year={2015},
  volume={9},
  pages={2793 - 2800}
}
Stigmasterol (99.9% pure) was isolated from Azadirachta indica and its chemopreventive effect on 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin cancer was investigated in Swiss albino mice. Skin tumors were induced by topical application of DMBA and promoted by croton oil. To assess the chemopreventive potential of stigmasterol, it was orally administered at a concentration of 200 mg/kg and 400 mg/kg three times weekly for 16 weeks. Reduction in tumor size and cumulative number of… Expand
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