Isolation and distribution of endomorphins in the central nervous system.

@article{Zadina2002IsolationAD,
  title={Isolation and distribution of endomorphins in the central nervous system.},
  author={James E. Zadina},
  journal={Japanese journal of pharmacology},
  year={2002},
  volume={89 3},
  pages={
          203-8
        }
}
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, EM-2) have the highest affinity and selectivity for the mu-opioid receptor (MOP-R) of all known mammalian opioids. They were isolated from bovine and human brain, and are structurally distinct from the other endogenous opioids. Both EM-1 and EM-2 have potent antinociceptive activity in a variety of animal models of acute, neuropathic and allodynic pain. They regulate cellular signaling processes in a manner… CONTINUE READING

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