• DOI:10.1055/s-0031-1298175
• Corpus ID: 43093559

Isolation and cytotoxic activity of selaginellin derivatives and biflavonoids from Selaginella tamariscina.

@article{Zhang2012IsolationAC,
  title={Isolation and cytotoxic activity of selaginellin derivatives and biflavonoids from Selaginella tamariscina.},
  author={Guo-gang Zhang and Ying Jing and Hong-Mei Zhang and En-long Ma and Jin Guan and Feng-ning Xue and Hong-Xia Liu and Xiao-ya Sun},
  journal={Planta medica},
  year={2012},
  volume={78 4},
  pages={
          390-2
        }
}

• Guo-gang Zhang, Ying Jing, +5 authors Xiao-ya Sun
• Published 23 January 2012
• Biology, Chemistry
• Planta medica

Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin ( 6), hinokiflavone (7), pulvinatabiflavone (8), and 7''- O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1- 9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines.