Isolation and culture of synovial microvascular endothelial cells. Characterization and assessment of adhesion molecule expression.

@article{Abbot1992IsolationAC,
  title={Isolation and culture of synovial microvascular endothelial cells. Characterization and assessment of adhesion molecule expression.},
  author={Stewart E. Abbot and Arvind Kaul and Cliff R Stevens and David R. Blake},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 4},
  pages={401-6}
}
OBJECTIVE In vitro studies investigating the role of the synovial endothelium in the pathogenesis of rheumatoid arthritis (RA) have, until recently, been performed using cultured endothelial cells of nonsynovial macrovascular origin. In an attempt to more correctly model in vivo conditions, a method for the isolation and culture of synovial microvascular endothelial cells (SMEC) has been developed. METHODS SMEC were isolated, primarily, by the use of lectin-coated (Ulex europaeus agglutinin… CONTINUE READING

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