Isolation and culture of adult mouse cardiac myocytes.

  title={Isolation and culture of adult mouse cardiac myocytes.},
  author={Timothy D. O'Connell and Manoj C Rodrigo and Paul C. Simpson},
  journal={Methods in molecular biology},
Cardiac myocytes are activated by hormonal and mechanical signals and respond in a variety of ways, from altering contractile function to inducing cardio-protection and growth responses. The use of genetic mouse models allows one to examine the role of cardiac-specific and other genes in cardiac function, hypertrophy, cardio-protection, and diseases such as ischemia and heart failure. However, studies at the cellular level have been hampered by a lack of suitable techniques for isolating and… CONTINUE READING


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