Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster.

@article{Silva1996IsolationAC,
  title={Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster.},
  author={Juan Carlos Noriega Silva and Robert E Minto and Clifton E Barry and Katalin A. Holland and Craig A Townsend},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 23},
  pages={13600-8}
}
Versicolorin B synthase catalyzes the side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolorin B, an essential transformation in the aflatoxin biosynthetic pathway of Aspergillus parasiticus. The dihydrobisfuran is key to the mutagenic nature of aflatoxin B1. The protein, which shows 58% similarity and 38% identity with glucose oxidase from Aspergillus niger, possesses an amino-terminal sequence homologous to the ADP-binding region of other… CONTINUE READING

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