Isolation and characterization of the mycobacterial phagosome: segregation from the endosomal/lysosomal pathway.

@article{Hasan1997IsolationAC,
  title={Isolation and characterization of the mycobacterial phagosome: segregation from the endosomal/lysosomal pathway.},
  author={Z Hasan and C Schlax and Lotte Kuhn and Ivan Lefkovits and Douglas Brownlee Young and Jelle E. R. Thole and Jean Pieters},
  journal={Molecular microbiology},
  year={1997},
  volume={24 3},
  pages={545-53}
}
Mycobacteria have the ability to persist within host phagocytes, and their success as intracellular pathogens is thought to be related to the ability to modify their intracellular environment. After entry into phagocytes, mycobacteria-containing phagosomes acquire markers for the endosomal pathway, but do not fuse with lysosomes. The molecular machinery that is involved in the entry and survival of mycobacteria in host cells is poorly characterized. Here we describe the use of organelle… CONTINUE READING

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